AI Article Synopsis
- Many solid tumors spread to bones, leading to serious health issues and decreased quality of life for patients.
- Current methods for studying bone tumor growth mainly use bioluminescent imaging, which doesn't track physical changes in bone structure.
- This text introduces a new scoring system for evaluating bone lesions through longitudinal radiographs that accounts for both tumor impact and bone damage.
Article Abstract
Many types of solid tumors metastasize to the bone, where it causes significant morbidity and mortality in patients with advanced disease. Bone metastases are not only incurable but also affect bone health which impairs patients' quality of life. In order to understand the mechanisms and develop effective treatments for bone-metastatic disease, it is first necessary to develop animal models that permit the assessment of tumor growth in the bone and progressive structural changes of the bone simultaneously. Longitudinal analysis of bone tumor progression is generally performed by bioluminescent imaging; however, this method is not able to assess progressive structural changes of the bone. Here, we describe a simple method for assessment of bone lesions using a scoring system that takes into account disease burden and bone destruction using longitudinal radiographs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082521 | PMC |
| http://dx.doi.org/10.1007/978-1-0716-1896-7_1 | DOI Listing |
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