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Recent Advancements in Localization Technologies for Wireless Capsule Endoscopy: A Technical Review.
Sensors (Basel)
January 2025
Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC 3800, Australia.
Conventional endoscopy is limited in its ability to examine the small bowel and perform long-term monitoring due to the risk of infection and tissue perforation. Wireless Capsule Endoscopy (WCE) is a painless and non-invasive method of examining the body's internal organs using a small camera that is swallowed like a pill. The existing active locomotion technologies do not have a practical localization system to control the capsule's movement within the body.
View Article and Find Full Text PDFSmall Extracellular Vesicles Derived from Cord Blood Plasma and Placental Mesenchymal Stem Cells Attenuate Acute Lung Injury Induced by Lipopolysaccharide (LPS).
Int J Mol Sci
December 2024
Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Sepsis is a risk factor associated with increasing neonatal morbidity and mortality, acute lung injury, and chronic lung disease. While stem cell therapy has shown promise in alleviating acute lung injury, its effects are primarily exerted through paracrine mechanisms rather than local engraftment. Accumulating evidence suggests that these paracrine effects are mediated by mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs), which play a critical role in immune system modulation and tissue regeneration.
View Article and Find Full Text PDFExperimental Study on the Elastic Support in a Discrete Rail Fastening System Used in Ballastless Tram Track Structures.
Materials (Basel)
January 2025
Faculty of Civil Engineering, Warsaw University of Technology, Al. Armii Ludowej 16, 00-637 Warsaw, Poland.
This paper presents an experimental study on the elastic support in a discrete rail fastening system used in a ballastless tram track structure. The study focuses on the elastic support of the anchor element, specifically the Pm49 baseplate. These elements significantly influence environmental pollution along tram routes, such as vibration (at low frequencies) or noise (at high frequencies), as well as static and dynamic rail deflections.
View Article and Find Full Text PDFLentivirus-mediated gene therapy for Fabry disease: 5-year End-of-Study results from the Canadian FACTs trial.
Clin Transl Med
January 2025
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Background: Fabry disease is an X-linked lysosomal storage disorder due to a deficiency of α-galactosidase A (α-gal A) activity. Our goal was to correct the enzyme deficiency in Fabry patients by transferring the cDNA for α-gal A into their CD34+ hematopoietic stem/progenitor cells (HSPCs). Overexpression of α-gal A leads to secretion of the hydrolase; which can be taken up and used by uncorrected bystander cells.
View Article and Find Full Text PDFAppearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice.
Microbiol Spectr
January 2025
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Unlabelled: Studies have suggested that phytochemicals in green tea have systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to the differential metabolism of phytochemicals resulting from variations in gut microbiome composition. To unravel this complex relationship, our team utilized a novel combined microbiome analysis and metabolomics approach applied to low complexity microbiome (LCM) and human colonized (HU) gnotobiotic mice treated with an acute dose of powdered matcha green tea.
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