AI Article Synopsis
- The study examines how early fusion of minor skull sutures affects skull-base growth in patients with Crouzon syndrome, focusing on the occipital bone and foramen magnum development.
- Researchers analyzed CT scans and 3D models from 60 patients with Crouzon syndrome under 12 years old, compared to 60 control patients, to understand the correlation between suture fusion and bone growth.
- Results show that while premature suture fusion limits the growth of various occipital bones, it does not directly cause foramen magnum shape restrictions, suggesting that this fusion impacts skull morphology in a broader context.
Article Abstract
To identify skull-base growth patterns in Crouzon syndrome, we hypothesized premature minor suture fusion restricts occipital bone development, secondarily limiting foramen magnum expansion. Skull-base suture closure degree and cephalometric measurements were retrospectively studied using preoperative computed tomography (CT) scans and multiple linear regression analysis. Evaluation of multi-institutional CT images and 3D reconstructions from Wake Forest's Craniofacial Imaging Database (WFCID). Sixty preoperative patients with Crouzon syndrome under 12 years-old were selected from WFCID. The control group included 60 age- and sex-matched patients without craniosynostosis or prior craniofacial surgery. None. 2D and 3D cephalometric measurements. 3D volumetric evaluation of the basioccipital, exo-occipital, and supraoccipital bones revealed decreased growth in Crouzon syndrome, attributed solely to premature minor suture fusion. Spheno-occipital (β = -398.75; < .05) and petrous-occipital (β = -727.5; < .001) suture fusion reduced growth of the basioccipital bone; lambdoid suture (β = -14 723.1; < .001) and occipitomastoid synchondrosis (β = -16 419.3; < .001) fusion reduced growth of the supraoccipital bone; and petrous-occipital suture (β = -673.3; < .001), anterior intraoccipital synchondrosis (β = -368.47; < .05), and posterior intraoccipital synchondrosis (β = -6261.42; < .01) fusion reduced growth of the exo-occipital bone. Foramen magnum morphology is restricted in Crouzon syndrome but not directly caused by early suture fusion. Premature minor suture fusion restricts the volume of developing occipital bones providing a plausible mechanism for observed foramen magnum anomalies.
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| http://dx.doi.org/10.1177/10556656211072762 | DOI Listing |
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