The prevalence of recombinant forms has greatly enhanced HIV-1 genetic diversity. Under co-circulation of major epidemic HIV-1 strains (CRF01_AE and CRF07_BC) in China, more CRF01_AE and CRF07_BC as the backbone of HIV-1 second-generation recombinants (SGRs) are also emerging. In this study, we identified three similar novel HIV-1 SGR strains composed of CRF01_AE and CRF07_BC from HIV-1 positive individuals in Shenzhen, China. Near full-length genome phylogenetic and recombinant analysis confirmed that these unique recombination forms were CRF01_AE and CRF07_BC strains recombined. Further subregion phylogenetic analysis indicated that all CRF01_AE fragments were from CRF01_AE cluster 4 prevalent among men who have sex with men, and all subtype B and C fragments derived from CRF07_BC. The emergence of novel recombinants of CRF01_AE/CRF07_BC indicates the increased genetic diversity of the HIV epidemic in Shenzhen. It is necessary to monitor HIV-1 SGR strains among high-risk populations for the epidemic dynamics of HIV-1 in Shenzhen, China.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/AID.2021.0211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Performance of a novel viral load assay for plasma HIV-1 RNA quantification compared with Roche real time PCR in China.
J Virol Methods
December 2024
Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China. Electronic address:
The aim of this study was to compare the Sansure HIV-1 VL assay with the Roche Cobas HIV-1 assay in the quantitation of HIV-1 VL and evaluate its application in China. We collected plasma samples from patients infected with HIV-1 or interference patients infected with other viruses. The same samples were subsequently tested using the Sansure HIV-1 VL and Roche Cobas HIV-1 VL assays.
View Article and Find Full Text PDFNational and Regional Molecular Epidemiology of HIV-1 - China, 2004-2023.
China CDC Wkly
November 2024
National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Beijing, China.
Introduction: The genetic diversity of human immunodeficiency virus (HIV)-1 subtypes significantly influences the effectiveness of diagnostic tools, antiretroviral therapy (ART), and vaccine development. This study aimed to assess the regional and national prevalence of HIV-1 subtypes and recombinants in China between 2004 and 2023 using pol gene segment analysis.
Methods: We analyzed annual HIV/AIDS reports and pol gene segment sequences from all Chinese provinces between 2004 and 2023.
Genetic characterization of a novel HIV-1 circulating recombinant form (CRF162_cpx) involving CRF01_AE, CRF07_BC and subtype B in Guangdong, China.
Virus Genes
December 2024
Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510440, China.
Human immunodeficiency virus type 1 (HIV-1) is characterized by its extremely high level of genetic diversity. The spread of different subtypes in the same population often leads to the emergence of circulating recombinant forms (CRFs) and unique recombinant forms (URFs). At present, the main recombinant subtypes of HIV-1 in China originate from CRF07_BC, CRF01_AE, CRF55_01B and subtype B.
View Article and Find Full Text PDFGenetic Characteristics of the Env Regions in HIV-1-Infected Subjects in Baoding City, Hebei Province, China.
Curr HIV Res
December 2024
Clinical Laboratory of the People's Hospital of Baoding, Baoding, Hebei, 071000, China.
Article Synopsis
- The study focuses on the envelope glycoprotein (Env) of HIV-1, which is essential for the virus's ability to infect host cells and is a key target for vaccines and therapies.
- Researchers analyzed the genetic characteristics of the Env gene in 145 newly diagnosed HIV-1 patients in Baoding City, successfully sequencing 142 samples and predicting coreceptor usage.
- Results indicated that 50% of the patients were infected with CCR5-tropic viruses, and specific subtypes showed trends in coreceptor preferences and similarities in the V3 loop's net charges, enhancing insights for vaccine and treatment development.
Analysis of genotype resistance and HIV-1 transmission risk in HIV-1-infected men who have sex with men in Guiyang, China.
Immun Inflamm Dis
November 2024
Department of Laboratory, Guiyang Public Health Clinical Center, Guiyang, China.
Background: As the social economy has developed and population mobility has increased, differences in the Human immunodeficiency virus type 1 (HIV-1) genotype distribution among men who have sex with men (MSM) have become apparent in the provinces and cities across China. The high variability and drug resistance characteristics of HIV-1 can lead to the widespread spread of resistant strains, which may also result in antiretroviral therapy failure and an increase in the mortality rate.
Objective: The genotypic drug resistance characteristics and HIV-1 transmission risks among HIV-1-infected MSM in Guiyang, Guizhou Province were analyzed in the current study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!