Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: This study aimed to evaluate the levels of total matrix metalloproteinase-8 (MMP-8), macrophage-activating factors (MAF), macrophage inflammatory protein (MIP)-1α, macrophage colony-stimulating factor (M-CSF), interleukin (IL)-34 in saliva, and serum of periodontally healthy, periodontitis Stage III Grade B (P-III-B) and Grade C (P-III-C) participants and to compare the changes after non-surgical periodontal treatment (NSPT).
Methods: A total of non-smoker and systemically healthy 65 participants, 20 periodontally healthy, 20 P-III-B, and 25 P-III-C were recruited for the study. The periodontal parameters were recorded, saliva and serum samples were obtained from all participants at baseline. In periodontitis groups, the periodontal parameters were reevaluated, and the samples were recollected at 1 and 3 months following the NSPT. MMP-8, MAF, MIP-1α, M-CSF, and IL-34 levels were measured by ELISA. Receiver operating characteristics curve was performed for estimating the area under the curve (AUC).
Results: All periodontal parameters were improved in periodontitis groups after NSPT (P < 0.05). Among tested molecules, salivary MMP-8 and MAF were higher in both periodontitis groups compared to healthy controls (P < 0.05) at baseline and significantly decreased after NSPT (P < 0.05) to healthy levels or below. Salivary MMP-8 had the highest diagnostic ability both for P-III-B (AUC:0.78 sensitivity: 80%; specificity: 80%) and P-III-C (AUC:0.88 sensitivity: 88%; specificity: 80%). Moreover, after adjusting for age, periodontitis groups were associated with salivary MMP-8 and MAF levels (P < 0.05).
Conclusion: The present study showed that high salivary MMP-8 and MAF levels were associated with non-smoker, systemically healthy P-III-B and P-III-C. Moreover, NSPT was remarkably reduced their levels.
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http://dx.doi.org/10.1002/JPER.21-0536 | DOI Listing |
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