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Effect of non-surgical periodontal treatment on salivary and serum biomarkers in Stage III Grade B and C periodontitis. | LitMetric

Background: This study aimed to evaluate the levels of total matrix metalloproteinase-8 (MMP-8), macrophage-activating factors (MAF), macrophage inflammatory protein (MIP)-1α, macrophage colony-stimulating factor (M-CSF), interleukin (IL)-34 in saliva, and serum of periodontally healthy, periodontitis Stage III Grade B (P-III-B) and Grade C (P-III-C) participants and to compare the changes after non-surgical periodontal treatment (NSPT).

Methods: A total of non-smoker and systemically healthy 65 participants, 20 periodontally healthy, 20 P-III-B, and 25 P-III-C were recruited for the study. The periodontal parameters were recorded, saliva and serum samples were obtained from all participants at baseline. In periodontitis groups, the periodontal parameters were reevaluated, and the samples were recollected at 1 and 3 months following the NSPT. MMP-8, MAF, MIP-1α, M-CSF, and IL-34 levels were measured by ELISA. Receiver operating characteristics curve was performed for estimating the area under the curve (AUC).

Results: All periodontal parameters were improved in periodontitis groups after NSPT (P < 0.05). Among tested molecules, salivary MMP-8 and MAF were higher in both periodontitis groups compared to healthy controls (P < 0.05) at baseline and significantly decreased after NSPT (P < 0.05) to healthy levels or below. Salivary MMP-8 had the highest diagnostic ability both for P-III-B (AUC:0.78 sensitivity: 80%; specificity: 80%) and P-III-C (AUC:0.88 sensitivity: 88%; specificity: 80%). Moreover, after adjusting for age, periodontitis groups were associated with salivary MMP-8 and MAF levels (P < 0.05).

Conclusion: The present study showed that high salivary MMP-8 and MAF levels were associated with non-smoker, systemically healthy P-III-B and P-III-C. Moreover, NSPT was remarkably reduced their levels.

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http://dx.doi.org/10.1002/JPER.21-0536DOI Listing

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