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Methodological standards for comparative effectiveness research: considerations for evidentiary review for medicare drug price negotiation.
Expert Rev Pharmacoecon Outcomes Res
January 2025
IQVIA, Durham, NC.
Introduction: The 2022 Inflation Reduction Act (IRA) is expected to result in lower drug prices for Medicare beneficiaries in the United States (US). The Centers for Medicare & Medicaid Services (CMS) released the most recent draft guidance for the Medicare Drug Price Negotiation (DPN) program in May 2024.
Areas Covered: In August 2023, the list of 10 drugs selected for the DPN were published and the first round of negotiations are now complete.
Evaluation of different artificial intelligence applications in responding to regenerative endodontic procedures.
BMC Oral Health
January 2025
Department of Endodontics, Faculty of Dentistry, Marmara University, Başıbüyük, Başıbüyük Yolu Marmara Üniversitesi Başıbüyük Sağlık Yerleşkesi 9/3, Başıbüyük - Maltepe, PO Box: 34854, İstanbul, Turkey.
Introduction: The integration of artificial intelligence (AI) technologies in healthcare is revolutionizing the workflows of healthcare professionals, enabling faster and more accurate patient treatment. This study aims to evaluate the accuracy of responses provided by different AI chatbots to questions that dentists might ask regarding regenerative endodontic treatment (RET), a procedure that shows promising biological healing potential.
Methods: A total of 23 questions related to RET procedures were developed based on the American Association of Endodontists (AAE) 2022 guidelines.
Effect of pharmaceutical pictograms on the textual comprehension of Prescription Medication Leaflets: A randomized controlled trial.
Res Social Adm Pharm
January 2025
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Spain.
Article Synopsis
- Clear patient instructions are crucial for effective pharmaceutical care, but there is a notable gap between the readability of medication information and the skills of many individuals, particularly Spanish adolescents.
- In a study involving 590 students, researchers assessed their understanding of Prescription Medication Leaflets for three medications, both with and without US Pharmacopeia (USP) pictograms, using questionnaires and health literacy assessments.
- Results revealed that comprehension was generally low and fell short of European standards, but the use of pictograms significantly improved understanding, especially for students with higher health literacy levels, indicating a need for better medication labeling strategies.
Pulmonary aspiration after activated charcoal in unintentional acute poisonings in childhood.
Arch Dis Child
January 2025
Pediatric Emergency Department, Cruces University Hospital Paediatric Emergencies, Barakaldo, Spain
Introduction: Although the administration of activated charcoal (AC) is considered safe, the associated risk of pulmonary aspiration explains certain reluctance of physicians to use this procedure. The objective of this study was to analyse the rate of pulmonary aspiration in children receiving AC after accidental ingestion of a toxic substance.
Methods: We carried out a substudy of a multicentre prospective registry-based cohort study including children presenting with acute poisoning to 58 paediatric emergency department (EDs) members of the Spanish Society of Pediatric Emergency Medicine between 2008 and 2022 on certain previously designated days.
The first five years of implementing Missouri's medication first approach to opioid use disorder treatment: Plateaus, regressions, and underbellies of progress.
J Subst Use Addict Treat
January 2025
University of Missouri-St. Louis, Addiction Science, Missouri Institute of Mental Health, 1 University Blvd., Benton Hall, Room 206, St. Louis, MO 63121, USA.
Introduction: Missouri's Medication First ("MedFirst") approach promotes same-day and long-term low-threshold access to medications for opioid use disorder (MOUD). Since 2017, Missouri's SAMHSA-funded State Targeted and State Opioid Response (STR/SOR) grants have supported MedFirst services (both medical and psychosocial) for uninsured individuals with opioid use disorder at state-contracted treatment programs. Though MedFirst demonstrated early success, results - with attention to possible racial disparities - must be revisited after five years of implementation.
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