AI Article Synopsis
- Researchers developed vertically paired electrodes (VPEs) to enhance capacitive measurements by optimizing the electrode gap and increasing the number of electrode pairs, using a conductive polymer (PEDOT:PSS) instead of traditional metal electrodes to improve fabrication yield.
- A model for an immunoassay demonstrated that reducing the electrode gap and increasing pairs significantly improved sensitivity, supported by computer simulations.
- The VPEs were successfully applied in detecting the SARS-CoV-2 nucleoprotein, achieving a detection limit that meets medical diagnosis standards and showing comparable results to a commercial rapid diagnostic kit.
Article Abstract
Vertically paired electrodes (VPEs) with multiple electrode pairs were developed for the enhancement of capacitive measurements by optimizing the electrode gap and number of electrode pairs. The electrode was fabricated using a conductive polymer layer of PEDOT:PSS instead of Ag and Pt metal electrodes to increase the VPE fabrication yield because the PEDOT:PSS layer could be effectively etched using a reactive dry etching process. In this study, sensitivity enhancement was realized by decreasing the electrode gap and increasing the number of VPE electrode pairs. Such an increase in sensitivity according to the electrode gap and the number of electrode pairs was estimated using a model analyte for an immunoassay. Additionally, a computer simulation was performed using VPEs with different electrode gaps and numbers of VPE electrode pairs. Finally, VPEs with multiple electrode pairs were applied for SARS-CoV-2 nucleoprotein (NP) detection. The capacitive biosensor based on the VPE with immobilized anti-SARS-CoV-2 NP was applied for the specific detection of SARS-CoV-2 in viral cultures. Using viral cultures of SARS-CoV-2, SARS-CoV, MERS-CoV, and CoV-strain 229E, the limit of detection (LOD) was estimated to satisfy the cutoff value (dilution factor of 1/800) for the medical diagnosis of COVID-19, and the assay results from the capacitive biosensor were compared with commercial rapid kit based on a lateral flow immunoassay.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741629 | PMC |
| http://dx.doi.org/10.1016/j.bios.2022.113975 | DOI Listing |
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