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Anti-angiogenic and anti-oxidant effects of 2-NTI indole derivative vs. suramin in ex vivo, in vivo, and in vitro studies.
Cytotechnology
February 2025
Department of Pharmacology and Toxicology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq.
Angiogenesis is an intricate pathway that involves the formation of new blood capillaries from old, functioning ones. Improper angiogenesis is a feature of numerous maladies, including malignancy and autoimmune disorders. Indole-related derivatives are believed to interfere with the mitotic spindle, inhibiting the multiplication, and invasion of cancerous human cells.
View Article and Find Full Text PDFIon channel traffic jams: the significance of trafficking deficiency in long QT syndrome.
Cell Discov
January 2025
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. Ion channel variants and many drugs can alter the cardiac action potential and lead to arrhythmias by interfering with mechanisms like ion channel synthesis, trafficking, gating, permeation, and recycling. A case in point is the Long QT syndrome (LQTS), a highly arrhythmogenic disease characterized by an abnormally prolonged QT interval on ECG produced by variants and drugs that interfere with the action potential.
View Article and Find Full Text PDFBackground: Older adults with mild cognitive impairment (MCI) are known to have declines in cognition greater than that expected for an individual's age and education level but does not significantly interfere with daily functioning. Memory impairments during the early stages of MCI may predict conversion to Alzheimer's disease (AD). This impairment can be especially prominent in associative memory - the ability to learn and remember the relationship between two unrelated items.
View Article and Find Full Text PDFMetal-Catalyzed Abiotic Cleavage of C═C Bonds for Effective Fluorescence Imaging of Cu(II) and Fe(III) in Living Systems.
Adv Sci (Weinh)
January 2025
Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Imaging abnormal copper/iron with effective fluorescent tools is essential to comprehensively put insight into many pathological events. However, conventional coordination-based detection is mired in the fluorescence quenching induced by paramagnetic Cu(II)/Fe(III). Moreover, the strong chelating property of the probe will consume dissociative metal ions and inevitably interfere with the physiological microenvironment.
View Article and Find Full Text PDFDICCR: Double-gated intervention and confounder causal reasoning for vision-language navigation.
Neural Netw
December 2024
School of Computer and Electronic Information, Guangxi University, University Road, Nanning, 530004, Guangxi, China. Electronic address:
Vision-language navigation (VLN) is a challenging task that requires agents to capture the correlation between different modalities from redundant information according to instructions, and then make sequential decisions on visual scenes and text instructions in the action space. Recent research has focused on extracting visual features and enhancing text knowledge, ignoring the potential bias in multi-modal data and the problem of spurious correlations between vision and text. Therefore, this paper studies the relationship structure between multi-modal data from the perspective of causality and weakens the potential correlation between different modalities through cross-modal causality reasoning.
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