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Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment.
Int J Parasitol Drugs Drug Resist
December 2024
Wellcome Sanger Institute, Cambridgeshire, United Kingdom. Electronic address:
Concerns about the emergence of benzimidazole resistance in soil-transmitted helminths (STH) infections, particularly against Trichuris trichiura, have arisen. Previous studies of veterinary nematodes have linked benzimidazole resistance to single-nucleotide polymorphisms (SNPs) at three specific codons in the beta-tubulin gene, but similar associations in STH have not been consistently observed. In this work, we screened the complete beta-tubulin gene previously linked to benzimidazole resistance in T.
View Article and Find Full Text PDFCassia alata: Helminth and Bacteria Fighter.
Comb Chem High Throughput Screen
October 2024
Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
Introduction: The concurrent presence of helminthiasis and bacterial diseases imposes a dual burden, worsening the challenges associated with each condition independently. This cohabitation intensifies the economic impact, creating a compounding effect on public health and economic well-being.
Method: Phytochemical analysis of Cassia alata Extract (CAE) using infrared spectroscopy has revealed the presence of various functional groups.
Effectiveness of benzimidazole treatments against Haemonchus contortus in sheep and goats - Do they produce similar responses?
Vet Parasitol
December 2024
Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, Košice 040 01, Slovakia. Electronic address:
The primary aim of this study was to compare the in vivo responses to orally administered doses of albendazole (5 mg/kg body weight) between experimentally infected sheep and goats. Fifty-four Improved Valachian lambs and 54 Saanen goat kids were split into six groups of nine animals. The sheep and goats were infected with larvae of the gastrointestinal nematode parasite Haemonchus contortus containing 10, 20, 30, 40, 60, and 80 % of the isotype-1 β-tubulin gene codon 200 alleles previously shown to be associated with benzimidazole (BZ)-resistance.
View Article and Find Full Text PDFPrevalence of cysticercosis in domestic pigs following albendazole deworming intervention in rural communities of Mbulu district, Tanzania.
Food Waterborne Parasitol
September 2024
Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, P.O. Box 447, Arusha, Tanzania.
Taeniosis and cysticercosis are infections caused by cestodes, is among them. neurocysticercosis accounts for 30% of acquired epilepsy in human in developing countries. This study was carried out to determine the prevalence of cysticercosis among domestic pigs in Mbulu district following deworming intervention.
View Article and Find Full Text PDFCYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children.
Sci Rep
May 2024
Department of Global Public Health, Karolinska Institutet, Karolinska University Hospital, Tomtebodavägen 18A, 171 77, Stockholm, Sweden.
Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes. Periodic school-based mass drug administration (MDA) with PZQ is the core intervention to control schistosomiasis.
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