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Oral health-related conditions in Ecuador: A temporal trend analysis of hospital discharges from 2000-2023.
PLoS One
January 2025
Escuela de Odontología, Universidad Internacional del Ecuador, Quito, Ecuador.
Background: Monitoring hospitalization rates associated with oral health conditions is an important part of epidemiological surveillance, especially when these conditions have increased significantly in low-and middle-income countries. This study aimed to evaluate the temporal trends in hospital discharges associated with oral health-related conditions in Ecuador from 2000 to 2023 and identify the leading diagnoses groups.
Methods: An ecological time-series study was conducted based on annual data from the National Institute of Statistics and Censuses of Ecuador.
Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome.
Cell Death Discov
January 2025
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. Our previous studies demonstrated that mutations associated with AEC syndrome lead to p63 protein misfolding and aggregation, exerting a dominant-negative effect.
View Article and Find Full Text PDFEvaluation of the effects of the third molar on distalization and the effects of attachments on distalization and expansion with clear aligners: Three-dimensional finite element study.
Korean J Orthod
January 2025
Department of Orthodontics, Hacettepe University, Ankara, Türkiye.
Objective: This study aimed to evaluate the effects of attachment design on maxillary molar distalization and simultaneous expansion during distalization, and the influence of third molars on distalization in the clear aligner technique using the finite element method.
Methods: Six models were created to evaluate three different attachment designs on the second molars. Model I: employed a vertical rectangular attachment; Model II: used a vertical rectangular attachment with the presence of the third molar; Model III: used a combined semi-elliptical attachment; and Model IV: featured an opposed semi-elliptical attachment with buccal and palatal components.
Epidemiologic trends of cleft lip and/or palate in Switzerland.
BMC Oral Health
January 2025
Laboratory for Oral Molecular Biology, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Freiburgstrasse 3, Bern, 3010, Switzerland.
Background: Epidemiologic data on the number of cleft lip and/or palate (orofacial cleft (OFC)) births in Switzerland are currently sparse. However, this knowledge is essential for better understanding the etiologies underlying the various cleft phenotypes and providing expectant parents with the best possible healthcare planning and counseling.
Methods: This is the first descriptive study to report data on the prevalence of the various cleft types, their sex, and regional distributions in Switzerland.
Oral and Maxillofacial Manifestations of Kallmann Syndrome: A Systematic Analysis of the Literature.
Spec Care Dentist
January 2025
Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
Aims: Kallmann syndrome (KS) is a rare genetic disorder characterized by congenital hypogonadotropic hypogonadism and varied clinical features. Despite its recognition, the oral and maxillofacial manifestations remain poorly understood. This study synthesized clinical aspects and management of KS-related oral and maxillofacial alterations.
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