AI Article Synopsis
- * This study focused on Japanese quail to examine how PMS impacts the emotional reactions and cognitive skills of their F1 offspring, along with analyzing specific histone modifications in related brain regions.
- * Results showed that while PMS didn’t alter learning abilities, it did heighten emotional reactivity and led to an increased density of the H3K27me3 epigenetic marker in key brain areas, suggesting these changes could influence the observed behavioral outcomes.
Article Abstract
Prenatal maternal stress (PMS) influences many facets of offspring's phenotype including morphology, behaviour and cognitive abilities. Recent research suggested that PMS also induced epigenetic modifications. In the present study, we analysed, in the Japanese quail, the effects of PMS on the emotional reactivity and cognitive abilities of the F1 offspring. We also investigated in the hippocampus, the paraventricular hypothalamic nucleus and subnuclei of the arcopallium/amygdala the level of two histone post-translational modifications, H3K4me2 and H3K27me3, known to be impacted by stress. We found that PMS does not affect F1 quail's learning abilities but increases their emotional reactivity. Moreover, we demonstrated that PMS induced an increased density of H3K27me3 positive cells, in the hippocampus, paraventricular hypothalamic nucleus and dorsal nucleus of the amygdala, but not variations of H3K4me2. As these brain regions are involved in the control of vertebrates' emotional responses, the effect of PMS on the epigenetic mark H3K27me3 could possibly be a mechanism involved in the behavioural effects we observed in F1 quail.
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| http://dx.doi.org/10.1016/j.psyneuen.2022.105661 | DOI Listing |
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