AI Article Synopsis
- Mitochondrial DNA (mtDNA) copy number (CN) was studied in a large sample of over 408,000 people to see how it relates to various cardiometabolic diseases.
- Results showed that younger individuals (<65 years) had higher mtDNA CN levels as they aged, while older individuals (≥65 years) experienced a decline in mtDNA CN levels.
- Lower mtDNA CN levels were linked to increased risks of obesity, hypertension, diabetes, and hyperlipidemia, suggesting that mtDNA CN decline may play a role in age-related health issues.
Article Abstract
Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: among younger participants (<65 years of age), each additional 10 years of age was associated with 0.03 standard deviation (s.d.) higher level of mtDNA CN ( = 0.0014) versus a 0.14 s.d. lower level of mtDNA CN ( = 1.82 × 10) among older participants (≥65 years). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity ( = 5.6 × 10), hypertension ( = 2.8 × 10), diabetes ( = 3.6 × 10), and hyperlipidemia ( = 6.3 × 10). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758111 | PMC |
| http://dx.doi.org/10.1016/j.xgen.2021.100006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!