To report an unusual optical coherence tomography (OCT) finding, bilayered retinoschisis formation in the macular region, during non-arteritic anterior ischemic optic neuropathy (NAION). This is a case report of a patient with NAION and an unusual OCT finding, bilayered retinoschisis formation. A 62-year-old female presented with decreased visual acuity in her right eye for one year. The best-corrected visual acuity was determined as 20/ 160 and no abnormal anterior segment finding was found in the slit-lamb biomicroscopy. A pale optic disc was detected and a widespread peripapillary retinal nerve fiber layer (RNFL) thinning was observed in the fundus evaluation. In the macula OCT evaluation, retinoschisis and microcyst formations at the outer nuclear layer (ONL) in the central macula and additional retinoschisis formation at the inner nuclear layer (INL) in the temporal macula were observed. As far as we know, this is the first report to demonstrate an unusual co-existence of NAION and retinoschisis that also has an unusual formation. The clinicians should be informed of the possible effects of NAION on the macula in the course of the disease.
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http://dx.doi.org/10.22336/rjo.2021.51 | DOI Listing |
Rom J Ophthalmol
January 2022
University of Health Sciences, Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
To report an unusual optical coherence tomography (OCT) finding, bilayered retinoschisis formation in the macular region, during non-arteritic anterior ischemic optic neuropathy (NAION). This is a case report of a patient with NAION and an unusual OCT finding, bilayered retinoschisis formation. A 62-year-old female presented with decreased visual acuity in her right eye for one year.
View Article and Find Full Text PDFHum Gene Ther
July 2021
Henan Eye Institute, Henan Eye Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
To investigate whether exosome-associated adeno-associated virus (AAV) retinoschisin 1 (1) vector improved the transduction efficiency of 1 in the mouse retina. pAAV2-RS1-ZsGreen plasmid was constructed by homologous recombination. Exosome-associated AAV vectors containing human 1 gene (exosome-associated AAV [exo-AAV]2-RS1-ZsGreen) were isolated from producer cells' supernatant, and confirmed by transmission electron microscopy, nanoparticle tracking analysis, and western blotting.
View Article and Find Full Text PDFBiochemistry
August 2010
LBPS, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA.
Retinoschisin (RS1) is a retina-specific secreted protein encoding a conserved discoidin domain sequence. As an adhesion molecule, RS1 preserves the retinal cell architecture and promotes visual signal transduction. In young males, loss-of-function mutations in the X-linked retinoschisis gene (RS1) cause X-linked retinoschisis, a form of progressive blindness.
View Article and Find Full Text PDFOphthalmology
March 1998
Ocular Imaging Center, New York Eye and Ear Infirmary, New York, USA.
Objective: This study aimed to evaluate the ability and role of ultrasound biomicroscopy in imaging the peripheral retina, pars plana, and anterior choroid.
Design: The study design was a case series.
Participants: Seventeen eyes of 17 patients with a variety of clinical diagnoses involving the anterior portion of the posterior segment were studied.
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