The world has been confronting a health crisis for two years because of the COVID-19 pandemic. The context of the crisis has the form of the first wave and subsequent waves that varied depending on the country. Undoubtedly, Algeria is one of the countries that have suffered severely from this pandemic. The recent wave has been marked with the huge number of casualties given the poor preparation. The country's preparation issue will be more complicated. In other words, in the context of an expected 4th wave that is characterized with the appearance of the new Omicron variant B.1.1.529. Thus, this news will consider the situation comprehensively and will provide recommendations to minimize the potential damage that will result from the fourth wave, and to attempt to limit the spread of the virus. The updated measures aim at rising the opportunities of improving the health situation in the country in the near future.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692091 | PMC |
http://dx.doi.org/10.35772/ghm.2021.01117 | DOI Listing |
J Med Chem
January 2025
State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
A novel 2'-α-fluoro-2'-β--(fluoromethyl) purine nucleoside phosphoramidate prodrug has been designed and synthesized to treat SARS-CoV-2 infection. The SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp8) catalyzed in vitro RNA synthesis was effectively inhibited by the corresponding bioactive nucleoside triphosphate (). The cryo-electron microscopy structure of the C-RTC: complex was also determined.
View Article and Find Full Text PDFJMIR Public Health Surveill
January 2025
Buehler Center for Health Policy and Economics, Robert J. Havey, MD Institute for Global Health, Northwestern University, 420 E. Superior, Chicago, US.
Background: This study updates the COVID-19 pandemic surveillance in East Asia and the Pacific we first conducted in 2020 with two additional years of data for the region.
Objective: First, we measure whether there was an expansion or contraction of the pandemic in East Asia and the Pacific region when the World Health Organization (WHO) declared the end of the COVID-19 public health emergency of international concern on May 5, 2023. Second, we use dynamic and genomic surveillance methods to describe the dynamic history of the pandemic in the region and situate the window of the WHO declaration within the broader history.
J Proteome Res
January 2025
PPGEMN, School of Engineering, Mackenzie Presbyterian University & MackGraphe - Mackenzie Institute for Research in Graphene and Nanotechnologies, Mackenzie Presbyterian Institute, São Paulo, São Paulo 01302-907, Brazil.
Since late 2021, Omicron variants have dominated the epidemiological scenario as the most successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sublineages, driving new and breakthrough infections globally over the past two years. In this study, we investigated for the first time the host salivary response of COVID-19 patients infected with Omicron variants (BA.1, BA.
View Article and Find Full Text PDFInfect Dis Model
March 2025
Mathematical Sciences, School of Science, RMIT University, Melbourne, Australia.
This paper examines a recently developed statistical approach for evaluating the effectiveness of vaccination campaigns in terms of deaths averted. The statistical approach makes predictions by comparing death rates in the vaccinated and unvaccinated populations. The statistical approach is preferred for its simplicity and straightforwardness, especially when compared to the difficulties involved when fitting the many parameters of a dynamic SIRD-type model, which may even be an impossible task.
View Article and Find Full Text PDFInfect Drug Resist
January 2025
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkuo, Taiwan.
Objective: Early reports have indicated that the Omicron variant of coronavirus disease 2019 (COVID-19) may be associated with low mortality. However, the mortality rate of critical patients in Taiwan with COVID-19 caused by different variants has not been well described.
Methods: This retrospective cohort study was conducted at the Linkou Branch of Chang Gung Memorial Hospital, Taiwan, from April 2020 to September 2022.
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