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| http://dx.doi.org/10.1016/j.jdcr.2021.11.024 | DOI Listing |
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Comprehensive considerations for dermatologists: the application of FDG-PET in evaluating cutaneous lesions in pediatric Langerhans cell histiocytosis.
Front Med (Lausanne)
July 2024
The Intervention Center, Division of Technology and Innovation, Oslo University Hospital, Oslo, Norway.
Langerhans cell histiocytosis (LCH) is a complex disorder characterized by the clonal proliferation of Langerhans cells, primarily affecting children and adolescents. This condition exhibits a wide spectrum of clinical presentations, necessitating a multidisciplinary approach for diagnosis, treatment, and follow-up. Cutaneous manifestations of LCH are significant, mimicking common dermatoses and posing diagnostic challenges.
View Article and Find Full Text PDFSkin-limited Langerhans cell histiocytosis in an adult presenting as isolated, eroded, "kissing" intergluteal plaques.
JAAD Case Rep
December 2023
Department of Dermatology, University of Michigan, Ann Arbor, Michigan.
Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man.
JAAD Case Rep
February 2022
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
Cutaneous histiocytoses in children.
Histopathology
January 2022
Department of Pathology, Ambroise Paré Hospital, AP-HP, Boulogne, France.
Article Synopsis
- - Cutaneous histiocytoses are a diverse group of skin diseases marked by an abnormal buildup of cells resembling macrophages or dendritic cells, ranging from mild skin issues to severe multi-organ conditions.
- - Traditionally, these diseases were classified based on the characteristics of the pathological cells, specifically distinguishing Langerhans cell histiocytosis (LCH) from non-LCH types.
- - Recent developments in molecular pathology have led to a new classification system for histiocytoses that takes into account genetic changes, clinical features, and imaging results, with juvenile xanthogranuloma and LCH being common in children.
A Dose-Response Relationship to Radiotherapy for Cutaneous Lesions of Langerhans Cell Histiocytosis.
Case Rep Oncol Med
March 2021
Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, USA.
Langerhans cell histiocytosis (LCH) is a rare disease, afflicting approximately 4.6 and 1-2 per 1 million children and adults, respectively. While LCH can involve numerous organ systems such as the lung or bone, it is uncommon for the disease to be limited to the skin.
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