Diverse polyketides from the marine endophytic sp LV52: Structure determination and cytotoxic activities.

We report the isolation and characterization of five polyketides [alternariol (), alternariol-9-methyl ether (), altertoxin I (), altertoxin II () and tenuazonic acid ()] from the marine endophytic sp. LV52 derived from collected from the Red Sea at Nabq-Bay, Egypt. The chemical structures of compounds were identified by extensive 1D, 2D NMR, and HR mass measurements. Isolation and phenotypic and genotypic characterization of the producing fungus is reported. The antimicrobial activity of the produced extract and derived compounds was examined against a panel of test organisms. In addition, an cytotoxic activity of was performed against diverse cancer cell lines: HEPG2, HELA, A549 and PC3, revealing that compounds and are potentially cytotoxic against A549 and PC3 with EC of 0.73 µg/ml (2.69 µM) and 0.17 µg/ml (0.64 µM) for , and 0.40 µg/ml (1.15 µM) and 0.12 µg/ml (0.33 µM) for , respectively.