AI Article Synopsis
- Developed micro-sized hierarchical structures on PLLA surfaces to enhance cell adhesion and growth, using laser modification techniques.
- The structures feature round protrusions with specific dimensions, designed to increase surface roughness and promote non-cytotoxic interactions with cells.
- Experimental results showed that the laser-modified surfaces encouraged better adhesion of human fibroblasts and osteoblasts, while pathogenic bacteria adhered more uniformly, indicating potential for smart implants in regenerative medicine.
Article Abstract
In this research we developed a micro-sized hierarchical structures on a poly(l-lactide) (PLLA) surface. The obtained structures consist of round-shaped protrusions with a diameter of ~20 μm, a height of ~3 μm, and the distance between them ~30 μm. We explored the effect of structuring PLLA to design a non-cytotoxic material with increased roughness to encourage cells to settle on the surface. The PLLA films were prepared using the casting melt extrusion technique and were modified using ultra-short pulse irradiation - a femtosecond laser operating at λ = 1030 nm. A hierarchical microstructure was obtained resembling 'cookies on a tray'. The cellular response of fibro- and osteoblasts cell lines was investigated. The conducted research has shown that the laser-modified surface is more conducive to cell adhesion and growth (compared to unmodified surface) to such an extent that allows the formation of highly-selectively patterns consisting of living cells. In contrast to eukaryotic cells, the pathogenic bacteria Staphylococcus aureus covered modified and unmodified structures in an even, non-preferential manner. In turn, adhesion pattern of eukaryotic fungus Saccharomyces boulardii resembled that of fibro- and osteoblast cells rather than that of Staphylococcus. The discovered effect can be used for fabrication of personalized and smart implants in regenerative medicine.
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| http://dx.doi.org/10.1016/j.msec.2022.112648 | DOI Listing |
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Article Synopsis
- Developed micro-sized hierarchical structures on PLLA surfaces to enhance cell adhesion and growth, using laser modification techniques.
- The structures feature round protrusions with specific dimensions, designed to increase surface roughness and promote non-cytotoxic interactions with cells.
- Experimental results showed that the laser-modified surfaces encouraged better adhesion of human fibroblasts and osteoblasts, while pathogenic bacteria adhered more uniformly, indicating potential for smart implants in regenerative medicine.
[Healthy bread optimized in experimental situation: what will be the acceptability in real situation of consumption?].
Rev Fac Cien Med Univ Nac Cordoba
August 2019
Universidad de Buenos Aires, Escuela de Nutrición, Facultad de Medicina..
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