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Bilateral visual acuity decline in males with choroideremia: a pooled, cross-sectional meta-analysis. | LitMetric

AI Article Synopsis

  • Choroideremia is a rare genetic eye disease that leads to vision loss, making understanding the rate of visual acuity decline crucial for assessing new treatments.* -
  • A meta-analysis using data from various studies, including the NIGHT study, evaluated visual acuity decline in males with choroideremia, revealing significant changes before and after age cutoffs (33.8 and 39.1 years) for better- and worse-seeing eyes.* -
  • The findings indicate that, while there are significant differences in visual acuity decline rates between the two eyes up until around age 40, these rates become more similar after that age, highlighting a critical period for monitoring disease progression.*

Article Abstract

Background: Choroideremia is a rare inherited retinal disease that leads to blindness. Visual acuity (VA) is a key outcome measure in choroideremia treatment studies, but VA decline rates change with age. An accurate understanding of the natural deterioration of VA in choroideremia is important to assess the treatment effect of new therapies in which VA is the primary outcome measure. We conducted a meta-analysis of data on individuals with choroideremia to determine the rate of VA deterioration between the better- and worse-seeing eye (BSE and WSE, respectively).

Methods: Data were collected from the prospective Natural History of the Progression of Choroideremia (NIGHT) study (613 eyes, baseline data only), studies included in a recent meta-analysis, and studies identified in a targeted literature search performed on March 25, 2020, including individual best-corrected VA (BCVA) and age data in male individuals with choroideremia. Best-corrected VA decline rates (measured by logMAR units) by age and trends in BCVA decline rates in the BSE and WSE were evaluated.  RESULTS: Data from 1037 males (1602 eyes; mean age, 41.8 years) were included. Before and after an age cutoff of 33.8 years, BCVA decline rates for the WSE were 0.0086 and 0.0219 logMAR per year, respectively. Before and after an age cutoff of 39.1 years, BCVA decline rates for the BSE were 0.00001 and 0.0203 logMAR per year, respectively. Differences in absolute BCVA and decline rates increased between the 2 eyes until age ~ 40; thereafter, differences in absolute BCVA and decline rates were similar between eyes.

Conclusions: Using the largest choroideremia data set to date, this analysis demonstrates accelerated BCVA decline beginning between 30 and 40 years of age. Disparate interocular progression rates were observed before the transition age, with similar interocular progression rates after the transition age.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762852PMC
http://dx.doi.org/10.1186/s12886-022-02250-zDOI Listing

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