AI Article Synopsis
- The study investigates the role of CD39 expression in regulatory T cells (Tregs) and its connection to the severity of COVID-19 in both adults and juveniles.
- Researchers analyzed blood samples from 190 COVID-19 patients and 43 healthy controls using flow cytometry.
- Findings show that CD39 Tregs increase with disease severity in adults but decrease in juveniles, highlighting differences in immune response between age groups.
Article Abstract
COVID-19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID-19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10-color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39 Tregs increased with disease severity. In contrast, CD39 Tregs were decreased in juvenile patients in an age-dependent manner. Overall, our study reveals an interesting profile of CD39-expressing Tregs in adult and juvenile cases of COVID-19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID-19 cases.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015412 | PMC |
| http://dx.doi.org/10.1002/jmv.27593 | DOI Listing |
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