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The brain neuropeptides and STAT3 mediate the inhibitory effect of 17-β Estradiol on central leptin resistance in young but not aged female high-fat diet mice. | LitMetric

AI Article Synopsis

  • The study investigates the impact of aging and menopause on body composition and energy balance, focusing on the hormone estrogen (E2) and its role in metabolism.
  • Young female mice (both intact and ovariectomized) and aged mice underwent a high-fat diet and were divided into different treatment groups, including those receiving E2 and others receiving oil as a control.
  • Results showed that E2 treatment reduced weight gain and calorie consumption in young mice while improving their sensitivity to leptin, indicating that E2 has protective effects against obesity in younger individuals but varies with age.

Article Abstract

Aging and menopause effect on body composition and energy balance. Estrogen (E2) plays an important role in body's metabolism. The aim of the present study was to determine changes in leptin function in young intact and ovariectomized (OVX) animals in comparison to the aged animals treated with E2. Young (Intact and OVX 4 months) and aged (19-21 months) female mice were fed High-fat diet (HFD) for 12 weeks and, then they were divided into eight groups including: Intact + OIL, Intact + E2, Intact + Pair body weight (PBW), OVX + OIL, OVX + E2, OVX + PBW, Aged + OIL, and Aged + E2. E2 was administered subcutaneously every four days for four weeks. Responsiveness to leptin was assessed by measuring energy balance components. Results showed that eating HFD increased weight and calorie consumption in young mice, and chronic treatment with E2 decreased both these variables in young animals. E2 only improved the sensitivity to leptin in young animals. Treatment with E2 resulted in increased α-MSH neuropeptide, reduced NPY and AgRP neuropeptides in the brain, and decreased serum leptin in the young animals. Also, treatment with E2 increased the expression of p-STAT3 molecular level in the hypothalamic arcuate nucleus (ARC) in the young animals. Our results indicated that response to E2 depended on age and E2 protects young HFD fed mice from obesity and improves leptin sensitivity.

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Source
http://dx.doi.org/10.1007/s11011-021-00884-4DOI Listing

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