This study aimed to investigate the mechanism of Na/Ca-induced soy hull polysaccharide (SHP) migration in the mucus layer. The viscosity, potential, microstructure, SHP migration, and metabolite migration were analyzed. The results showed that Na had little effect on the viscosity of polysaccharides, while Ca increased the viscosity of polysaccharides. Na and Ca promoted the migration of SHP particles by reducing the zeta potential, while they decreased the migration of SHP chyle particles by increasing the aggregation. SHP was fermented by gut microbiota to produce a large number of short-chain fatty acids (SCFAs). Compared with Ca, Na increased the migration of total SCFAs in the mucus layer. The high-Na/Ca mucus internal environment had a specific effect on the transport of nutrients in the intestine.
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http://dx.doi.org/10.1016/j.ijbiomac.2022.01.016 | DOI Listing |
J Mater Chem B
January 2025
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Ibaraki 305-0044, Japan.
The colon possesses a unique physiological environment among human organs, where there is a highly viscous body fluid layer called the mucus layer above colonic epithelial cells. Dysfunction of the mucus layer not only contributes to the occurrence of colorectal cancer (CRC) but also plays an important role in the development of chemoresistance in CRC. Although viscosity is an essential property of the mucus layer, it remains elusive how viscosity affects chemoresistance in colon cancer cells.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Chemical Materials and Industrial Production (DICMaPI), University of Naples Federico II, P.le Tecchio 80, Naples 80125, Italy.
In recent years, nano and micro drug delivery systems targeting the colon have gained more attention due to increasing interest in treating colon diseases such as colorectal cancer and inflammatory bowel disease, , Crohn's disease and ulcerative colitis. Usually, nanocarriers are exploited for their enhanced permeability properties, allowing higher penetration effects and bioavailability, while microcarriers are primarily used for localized and sustained release. In bowel diseases, carriers must go into a delicate environment with a strict balance of gut bacteria (, colon), and natural or biodegradable polymers capable of ensuring lower toxicity are preferred.
View Article and Find Full Text PDFFoods
December 2024
College of Food Science, Shenyang Agricultural University, Shenyang 110866, China.
, a Gram-negative anaerobic bacterium colonizing the intestinal mucus layer, is regarded as a promising "next-generation probiotic". There is mounting evidence that diabetes and its complications are associated with disorders of abundance. Thus, and its components, including the outer membrane protein Amuc_1100, -derived extracellular vesicles (AmEVs), and the secreted proteins P9 and Amuc_1409, are systematically summarized with respect to mechanisms of action in diabetes mellitus.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Department of Chemistry, Northeast Normal University, Changchun 130024, PR China. Electronic address:
The oral administration of drugs for cancer therapy can maintain optimal blood concentrations, is biologically safe and simple, and is preferred by many patients. However, the complex lumen environment, mucus layer, and intestinal epithelial cells are biological barriers that hinder the absorption of orally administered drugs. In this study, sea urchin-like manganese-doped copper selenide nanoparticles (Mn-CuSe NPs) were designed using an anion exchange method and coated with calcium alginate and chitosan (AC) to form Mn-CuSe@AC capsules.
View Article and Find Full Text PDFPNAS Nexus
January 2025
Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0495, Japan.
Canopy flows occur when a moving fluid encounters a matrix of free-standing obstacles and are found in diverse systems, from forests and marine ecology to urban landscapes and biology (e.g. cilia arrays).
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