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Comparison of Efficacy and Safety of Device-Based Interventions Versus Pharmacological Therapy in the Management of Patients With Advanced Parkinson's Disease: A Literature Review.
Cureus
December 2024
College of Medicine, Almaarefa University, Riyadh, SAU.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms that profoundly impact patients' quality of life. While pharmacological therapies such as levodopa remain the mainstay of treatment, their long-term use is often limited by motor complications. Device-based interventions, including deep brain stimulation (DBS) and continuous dopaminergic infusions, have emerged as alternatives, promising sustained symptomatic control and reduced medication-related side effects.
View Article and Find Full Text PDFEvaluating the Safety and Usability of an Over-the-Counter Medical Device for Adults With Mild to Moderate Hearing Loss: Formative and Summative Usability Testing.
JMIR Hum Factors
January 2025
Center for Research and Innovation in Systems Safety, Department of Anesthesiology, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 800, Nashville, TN, 37203, United States, 16153431528.
Background: Only 15% of the nearly 30 million Americans with hearing loss use hearing aids, partly due to high cost, stigma, and limited access to professional hearing care. Hearing impairment in adults can lead to social isolation and depression and is associated with an increased risk of falls. Given the persistent barriers to hearing aid use, the Food and Drug Administration issued a final rule to allow over-the-counter hearing aids to be sold directly to adult consumers with perceived mild to moderate hearing loss at pharmacies, stores, and online retailers without seeing a physician or licensed hearing health care professional.
View Article and Find Full Text PDFNation-wide cohort of device-measured sedentary time and physical activity in the USA-the Cancer Prevention Study-3 (CPS-3) Accelerometry Substudy: cohort profile.
BMJ Open
January 2025
American Cancer Society, Atlanta, Georgia, USA.
Purpose: This paper describes the data collection and management methods for the Cancer Prevention Study-3 (CPS-3) Accelerometry Substudy, a nested cohort of device-based physical activity and sedentary time data.
Participants: US-based CPS-3 participants (initially enrolled 2006-2013) who completed the 2018 follow-up survey and had a valid email address were invited to the Accelerometry Substudy (n=109 780). Among the 23 111 participants who registered and were shipped an ActiGraph GT3X+ accelerometer, 21 219 participants returned the device with a complete wear log (91.
Focusing on microvascular function in heart failure with preserved ejection fraction.
Heart Fail Rev
January 2025
Department of Cardiology, Cardiology I, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.
Heart failure is a prevalent global health issue. Heart failure with preserved ejection fraction (HFpEF), which already represents half of all heart cases worldwide, is projected to further increase, driven by aging populations and rising cardiovascular risk factors. Effective therapies for HFpEF remain limited, particularly due to its pathophysiological heterogeneity and incomplete understanding of underlying pathomechanisms and implications.
View Article and Find Full Text PDFReal-World Treatment Outcomes of an Artificial Tear Containing Arabinogalactan, Hyaluronic Acid and Trehalose Among Subjects with Dry Eye.
Clin Ophthalmol
January 2025
Department of Research and Development, MD Italy, Albano Laziale, Italy.
Purpose: To assess the efficacy, adherence, and tolerability of a new artificial tear based on arabinogalactan, hyaluronic acid, and trehalose in a population with dry eye disease (DED).
Methods: A retrospective, real-world, post-marketing study identified 96 adult patients (aged 18-80 years) with signs and symptoms of dry eye. These patients received fixed combination therapy with eye drops containing arabinogalactan, hyaluronic acid, and trehalose at various dosing schedules.
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