In the last few years the derivative expansion of the nonperturbative renormalization group has proven to be a very efficient tool for the precise computation of critical quantities. In particular, recent progress in the understanding of its convergence properties allowed for an estimate of the error bars as well as the precise computation of many critical quantities. In this work we extend previous studies to the computation of several universal amplitude ratios for the critical regime of O(N) models using the derivative expansion of the nonperturbative renormalization group at order O(∂^{4}) for three-dimensional systems.
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http://dx.doi.org/10.1103/PhysRevE.104.064101 | DOI Listing |
Cell Death Differ
December 2024
Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.
Germline inactivating mutations of the SLC25A1 gene contribute to various human disorders, including Velocardiofacial (VCFS), DiGeorge (DGS) syndromes and combined D/L-2-hydroxyglutaric aciduria (D/L-2HGA), a severe systemic disease characterized by the accumulation of 2-hydroxyglutaric acid (2HG). The mechanisms by which SLC25A1 loss leads to these syndromes remain largely unclear. Here, we describe a mouse model of SLC25A1 deficiency that mimics human VCFS/DGS and D/L-2HGA.
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December 2024
Institute of Agrobiological Sciences, NARO, Tsukuba, Ibaraki, Japan.
Recent changes in climate and environments have promoted the range expansion of insect pests of tropical and subtropical origins into temperate regions. For more accurate and faster risk assessment of this expansion, we developed a novel indicator to link a physiologically derived parameter of chilling injury with the survival of insect populations in nature by using two insects, Spodoptera frugiperda and Cicadulina bipunctata with tropical and subtropical origins, and one cool-adapted insect, Laodelphax striatellus. The parameter derived from a proportional increment in the time to 99.
View Article and Find Full Text PDFExp Hematol Oncol
December 2024
Department of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical Center, Duarte, CA, USA.
Cytoplasmic proliferating cell nuclear antigen (PCNA) is highly expressed in acute myeloid leukemia (AML) cells, supporting oxidative metabolism and leukemia stem cell (LSC) growth. We report on AOH1996 (AOH), an oral compound targeting cancer-associated PCNA, which shows significant antileukemic activity. AOH inhibited growth in AML cell lines and primary CD34 + CD38 - blasts (LSC-enriched) in vitro while sparing normal hematopoietic stem cells (HSCs).
View Article and Find Full Text PDFImmunity
December 2024
Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address:
Thymic mimetic cells are molecular hybrids between medullary-thymic-epithelial cells (mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T cells and can perform supplementary functions reflective of their peripheral-cell counterparts. Current knowledge about mimetic cells derives largely from mouse models.
View Article and Find Full Text PDFCell Metab
December 2024
The Second Affiliated Hospital, School of Public Health, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou 310058, China; School of Public Health, Basic Medical Sciences, School of Pharmacology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China; School of Public Health, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China. Electronic address:
Ferroptosis is characterized as an iron-dependent and lipophilic form of cell death. However, it remains unclear what role ferroptosis has in adipose tissue function and activity. Here, we find a lower ferroptotic signature in the adipose tissue of individuals and mice with obesity.
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