Trichosporon colonizes the skin, vagina, gastrointestinal and respiratory tract of humans. Superficial infections are common, while disseminated trichosporonosis is rare, specifically seen among immunocompromised patients and often associated with high mortality. We report a rare case Trichosporon asahii infection in a 78-year-old diabetic, with associated acute interstitial glomerulonephritis. Molecular identification of the isolate was confirmed by sequencing IGS1 region of rDNA. Our study adds to a rather limited literature on renal complications of Trichosporonosis.
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| http://dx.doi.org/10.1016/j.mmcr.2021.12.001 | DOI Listing |
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Article Synopsis
- Trichosporon asahii is a harmful fungus that primarily affects people with weakened immune systems, leading to severe infections.
- Researchers faced challenges in studying its virulence due to the absence of effective animal models and genetic tools specific to this fungus.
- The study introduces a new method using silkworms for infection testing and a genetic technique to create mutants, aiding in the discovery of virulence factors associated with T. asahii.
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