AI Article Synopsis
- Spindle cell carcinoma (SpCC) is a rare form of squamous cell carcinoma that features both carcinomatous and sarcomatous traits, making diagnosis challenging.
- A case study highlighted a 50-year-old woman previously treated for melanoma, who presented with a painful lip lesion diagnosed as SpCC after surgical analysis showed specific immunohistochemical markers.
- The patient experienced metastases within a year, leading to her death after three years, emphasizing the need for detailed microscopic and immunohistochemical evaluations for accurate diagnosis.
Article Abstract
Introduction: Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma, is a rare variant of squamous cell carcinoma (SCC) that has a variable proportion of carcinomatous and sarcomatous components. Here, we reported an immunohistochemical study of a spindle cell carcinoma with a challenging morphological diagnosis.
Case Report: A 50-year-old woman with a previous history of nodular melanoma was referred for evaluation of a painful papule in the lower lip. After surgical resection, neoplastic cells showed focal positivity for CK-14, αSMA, p63, and confirmed the strong positivity for S100 and vimentin. Tumor cells were negative for HMB-45, Melan A, SOX-10, AE1/AE3, 34βE12, CK5-6, CAM5.2, EMA, desmin, calponin, CD10, CD34, and CD68. With these findings, a diagnosis of SpCC was rendered. The patient presented lung and dorsal metastases after 12 months and after 3 years of follow-up, the patient died.
Conclusion: In summary, a careful correlation of microscopy and immunohistochemical characteristics is required for the proper diagnosis of this lesion.
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| http://dx.doi.org/10.1016/j.oraloncology.2021.105680 | DOI Listing |
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