Prolonged sitting prevents a 1-h bout of running from improving fat oxidation and reducing plasma triglycerides. This "exercise resistance" can be prevented by taking 8500 steps·d-1 or by interrupting 8 h of sitting with hourly cycle sprints. We hypothesize that there is an interplay between background physical activity (e.g., steps·d-1) and the exercise stimuli in regulating some acute and chronic adaptations to exercise.
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