Vascular macrophages sense an odorant to induce atherosclerotic plaque formation.
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http://dx.doi.org/10.1126/science.abn4708 | DOI Listing |
Arch Clin Neuropsychol
April 2024
Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Objective: Quantitative olfactory assessment has demonstrated clinical utility for the evaluation of a range of neurologic, psychiatric, and sinonasal conditions. Here, we provide age, sex, race, and education-specific normative data for the 12-item Sniffin Sticks Odor Identification Test (SSOIT-12) in older Black and White U.S.
View Article and Find Full Text PDFInt J Mol Sci
March 2022
Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Science
January 2022
La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting odorants and the sense of smell. We found that mouse vascular macrophages express the olfactory receptor and all associated trafficking and signaling molecules.
View Article and Find Full Text PDFScience
January 2022
University of Ottawa Heart Institute, Ottawa, ON, Canada.
Vascular macrophages sense an odorant to induce atherosclerotic plaque formation.
View Article and Find Full Text PDFExpert Rev Mol Med
April 2016
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology,New Delhi,India.
Trimethylamine (TMA) is a tertiary amine with a characteristic fishy odour. It is synthesised from dietary constituents, including choline, L-carnitine, betaine and lecithin by the action of microbial enzymes during both healthy and diseased conditions in humans. Trimethylaminuria (TMAU) is a disease typified by its association with the characteristic fishy odour because of decreased TMA metabolism and excessive TMA excretion.
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