AI Article Synopsis
- A new method using Selectfluor allows for the efficient synthesis of β-acyl allyl sulfones and β-acyl allyl benzotriazoles from common starting materials like acetophenones and aryl acetylenes.
- DMSO is utilized as a dual-carbon source, enabling the creation of multiple carbon and sulfur or nitrogen bonds in a single reaction without the need for transition metals.
- This technique is versatile, successfully producing a variety of compounds, including using acetylenes as an alternative starting material.
Article Abstract
A Selectfluor-mediated approach for the synthesis of β-acyl allyl sulfones/β-acyl allyl benzotriazoles with excellent atom economy from readily available acetophenones/aryl acetylenes, aryl sulfinates/benzotriazoles, and dimethyl sulfoxide (DMSO) is described. In this protocol, DMSO acts as a dual-carbon synthon, resulting in a transition-metal-free construction of two C-C and one C-S or two C-C and one C-N bonds in one pot. This approach is extended to generate chemically diverse compounds. Additionally, β-acyl allyl sulfones/β-acyl allyl benzotriazoles were prepared from acetylenes instead of acetophenones.
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| http://dx.doi.org/10.1021/acs.joc.1c02348 | DOI Listing |
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