Background: Surgery for geriatric proximal femoral fractures (PF) is associated with high mortality rates within the first year. Studies with follow-up of at least 10 years after surgery are lacking.
Material And Methods: Based on our database, we reviewed patients with PF who underwent surgery and were followed for a minimum of 10 years. Only patients aged 65-99 years were included. The primary endpoint was survival compared to the mean life expectancy of the general population evaluated by the German Federal Statistical Office. The secondary endpoint was any revision later than 1 year after surgery. After a minimum of 10 years telephone calls were conducted with living patients or their relatives.
Results: From a total of 1203 consecutive patients 1000 patients with 1000 PF were evaluated after a mean of 12.2 years (range 10.0-14.0 years). The mean survival was 4.5 ± 1.6 years, and the 10-year survival rate was 13.1%. A total of 7 periods with a range of 5 years were analyzed, starting from 65-69 years up to 95-99 years. Compared to the mean life expectancy of the general population, the survival rate of the sample was significantly shorter up to 9 years. Both genders were equally affected. With increasing age, this gap declined based on shorter life expectancy. A subgroup analysis revealed that patients with survival > 1 year did not demonstrate significantly better results. Revisions later than 1 year after the index surgery were infrequent, and only 27 (2.7%) were recorded.
Conclusion: Geriatric patients with PF have significantly shorter life expectancy than the general population evaluated by the German Federal Statistical Office. This reflects fragility and morbidity of patients with PF.
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http://dx.doi.org/10.1007/s00113-022-01140-9 | DOI Listing |
Sci Rep
January 2025
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Intracerebral hemorrhage (ICH) represents one of the most devastating forms of stroke, characterized by spontaneous bleeding into the brain parenchyma. This neurological emergency carries a substantial burden of mortality and long-term disability worldwide. A comprehensive understanding of ICH's evolving global impact from 1990 to 2021 remains essential for healthcare planning and resource allocation.
View Article and Find Full Text PDFBJGP Open
January 2025
Department of Primary and Long-term Care, University Medical Center Groningen, Groningen, Netherlands.
Background: In individuals with depression a vicious circle tends to occur in which depressive symptoms cause an unhealthy lifestyle, which reversibly causes an increase in depressive symptoms; both of which are associated with a decreased life expectancy. A potential way to break this circle entails a multicomponent lifestyle intervention (MLI).
Aim: Exploring the barriers and facilitators for an MLI in patients with depressive symptoms from the perspective of general practitioners (GP), chronic disease practice nurses (CD-PN), mental health nurses (MHN), lifestyle coaches (LC) and patients (PT).
Int J Pharm
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137 China. Electronic address:
Hepatocellular carcinoma is one of the leading causes of cancer deaths globally and a key hindrance to extending life expectancy. Celastrol (CEL) demonstrates excellent antitumor activity, but faces challenges like low solubility and a narrow therapeutic window, limiting its clinical application. To address these limitations, drug combinations and nano-delivery systems have emerged as effective solutions.
View Article and Find Full Text PDFCad Saude Publica
January 2025
Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brasil.
This study aimed to describe the profile and calculate the years of potential life lost (YPLL) due to liver diseases in Brazilian agricultural workers from 2017 to 2022. For this, we analyzed microdata available in the Brazilian Mortality Information System considering the underlying cause of death with codes K70-K77 (International Classsification of Disease, 10th revision - ICD-10) as the outcome of interest. Workers' profile was characterized according to sociodemographic variables and Brazilian regions, forming a comparison group with all other Brazilian workers aged from 18-69 years who died in the same period and from the same underlying cause.
View Article and Find Full Text PDFNeurosurgery
January 2025
Division of Neurosurgery, Changi General Hospital, Singapore.
Background And Objective: The global average life expectancy has been increasing steadily as the quality of healthcare continues to improve. However, there is a paucity of data looking at surgical fixation of thoracolumbar spine fractures in patients ≥80 years (super-elderly). Aim of this study is to look at whether there is higher rate of complications from surgical fixation of thoracolumbar fractures in this group of patients.
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