Clonal Seborrheic keratosis: A Diagnostic Dilemma.

Dermatol Pract Concept

Sparkle Skin & Aesthetic Clinic, Vashi, Navi Mumbai, India.

Published: October 2021

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648421PMC
http://dx.doi.org/10.5826/dpc.1104a95DOI Listing

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Article Synopsis
  • The case study discusses an 89-year-old woman's rare skin condition involving clonal seborrheic keratosis (SK) accompanied by Bowen disease (BD), which is a form of squamous cell carcinoma in situ.
  • Histopathological analysis showed characteristics of both conditions, including abnormal cell growth and changes in cell structure, indicating a transformation from SK to BD.
  • The findings suggest that the lesions are interconnected rather than independent, highlighting a complex interaction where neoplastic cells in SK evolved into BD with sebaceous differentiation.
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Hidroacanthoma simplex (HS) is a rare benign intraepidermal tumor that originates in the acrosyringial portion of the eccrine duct. Clinically, they are well-defined lesions, flat or verrucous brownish plaque, and can be misdiagnosed with other types of benign or malignant tumors. Dermoscopy reveals small black globules and fine scales.

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Article Synopsis
  • - Seborrheic keratosis (SK) is the most common benign tumor from epithelial cells and its occurrence increases as people age.
  • - The exact cause of SK is not fully understood, but UV radiation exposure may play a role.
  • - SK lesions typically appear rough, slightly raised, and are usually black or brown, being mostly painless, although they can occasionally ooze or become ulcerated.
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