Genetic Pathways Involved in the Pathogenesis of Parkinson's Disease.

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD pathogenesis includes both genetic and environmental factors. Previous studies have linked the disease with several genes such as Parkin, SNCA, PINK1 and HTRA2. BiNGO software utilizes GO annotations in order to detect over-represented genes in terms of biological processes, cellular components and molecular functions. Three databases were utilized for this study (Ensembl, DisGeNET and UniProt). Data processing provided 110 genes associated with PD for further analysis. The aim of this study was to identify genes associated with PD and perform a functional enrichment analysis. Cytoscape and BiNGO software analysis presented several new genes that could play a potential role in pathogenesis of the disease. Future steps include additional research in order to establish the exact mechanism of action of these genes and pathways on PD.