Ebola Virus Disease and Current Therapeutic Strategies: A Review.

Adv Exp Med Biol

DarkDNA Group, Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece.

Published: January 2022

AI Article Synopsis

  • Ebola virus disease is a severe and highly contagious illness caused by the Ebola virus, primarily affecting humans and primates, with a fatality rate around 50%.
  • Since 1976, there have been 11 reported outbreaks, predominantly in sub-Saharan Africa, with the latest outbreak in the Democratic Republic of the Congo involving over 3000 cases and 72 deaths.
  • Although an effective vaccine exists, there is currently no targeted treatment proven to work after infection, prompting ongoing reviews of its epidemiology, prevention, diagnosis, and treatment strategies.

Article Abstract

The Ebola virus disease is a severe hemorrhagic fever that affects humans and other primates. Ebola virus, the causative agent of the disease, is transmitted to humans from wild animals and is highly contagious and aggressive with an estimated fatality rate to be around 50%. Since 1976, 11 outbreaks of Ebola virus disease have been reported in total, affecting mostly sub-Saharan Africa, while the most recent ongoing outbreak in the Democratic Republic of the Congo has more than 3000 reported cases and 72 deaths. Although an effective vaccine against Ebola virus disease has become available, no targeted treatment with proven efficacy upon infection is developed. Herein, we review the epidemiology of Ebola virus and the current situation in terms of prevention, diagnosis, and treatment of the disease.

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Source
http://dx.doi.org/10.1007/978-3-030-78787-5_18DOI Listing

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