AI Article Synopsis
- A specific genetic variation in the APOBEC3C enzyme, affecting a single amino acid (serine to isoleucine at position 188), is found in around 10% of African populations and significantly boosts the enzyme's ability to fight off HIV-1 and SIV.
- The study observed that this variant, APOBEC3CS188I, can edit the hepatitis B virus (HBV) both in lab cultures and in infected individuals.
- Utilizing next-generation sequencing, researchers discovered that this edited variant enhances activity in a specific DNA editing context (5'TpCpA to 5'TpTpA), marking a new understanding of the enzyme's function and potential implications for HBV and nuclear DNA.
Article Abstract
Single-nucleotide polymorphism in APOBEC3C (resulting in a serine to isoleucine in position 188) is present in approximately 10% of African populations and greatly enhances restriction against human immunodeficiency virus-1 and simian immunodeficiency virus by improving dimerization and DNA processivity of the enzyme. In this study, we demonstrated in culture and in infected patients that hepatitis B virus (HBV) could be edited by APOBEC3CS188I. Using next-generation sequencing, we demonstrated that APOBEC3CS188I led to enhanced editing activity in 5'TpCpA→5'TpTpA context. This constitutes a new hallmark of this enzyme, which could be used to determine its impact on HBV or nuclear DNA.
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| http://dx.doi.org/10.1093/infdis/jiac003 | DOI Listing |
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