Clinical Relevance: Knowledge of interactions between genetic variants and near-work activities at the onset of myopia can facilitate health education regarding myopia.
Background: To investigate the interactions between genetic variants ( and ) and near-work activities in the onset of myopia in southeastern Chinese school children.
Methods: A total of 458 non-myopic, grade 1 children aged 6-7 years were included in a 4-year follow-up examination; 409 children were assessed further. Manifest (non-cycloplegic) refraction and axial length (AL) were measured every year, and questionnaires were administered annually to assess information regarding the demographic characteristics of children, near-work activities, outdoor exposure and parental myopia. Oral mucosa was collected in the last year of follow-up, and Sanger sequencing was used to genotype single nucleotide polymorphisms (SNPs) in DNA.
Results: The cumulative change in the spherical equivalent refraction (SER) over 4 years was -1.20 ± 1.00 D, and the proportion of children with incident myopia was 42.9%. Multivariate logistic regression analysis showed that an increased amount of time spent doing homework (>2 h/d) was an independent risk factor for incident myopia. The rs12206610CT genotype and spending > 5 h/d on near-work activities showed an interaction for incident myopia (OR = 4.29, 95% CI: 1.27-14.53; nteraction = 0.02); moreover, the rs12206610CT genotype carriers who used electronic devices for > 1 h/d displayed an increased risk of incident myopia (OR = 3.43, 95% CI: 1.07-11.01; = 0.043).
Conclusions: The rs2206610CT genotype carriers with near-work activities of >5 h/d were more likely to show incident myopia, especially those who used electronic devices >1 h/d. However, interactions between the rs12206610 SNP and near-work activities require further verification in animal models and larger sample cohorts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/08164622.2021.2024070 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of defocus incorporated multiple segments (DIMS) lenses and low-dose atropine on retarding myopic shift among premyopic preschoolers: Protocol for a prospective, multicenter, randomized controlled trial.
PLoS One
December 2024
Department of Ophthalmology, Lotung Poh-Ai Hospital, Lo-Hsu Medical Foundation, Incorporation, Yilan, Taiwan.
Background: Myopia has been a rising problem globally. Early-onset myopia significantly increases the risk of high myopia later in life. Despite the proven benefits of increased outdoor time, optimal strategies for preventing early-onset myopia in premyopic children need further investigation.
View Article and Find Full Text PDFEvaluating the Effectiveness and Scalability of the World Health Organization MyopiaEd Digital Intervention: Mixed Methods Study.
JMIR Public Health Surveill
December 2024
Center for Global Development, Yonsei Institute for Global Health, Yonsei University Health System, Seoul, Republic of Korea.
Background: The rapid rise of myopia worldwide, particularly in East and Southeast Asia, has implied environmental influences beyond genetics. To address this growing public health concern, the World Health Organization and International Telecommunication Union launched the MyopiaEd program. South Korea, with its high rates of myopia and smartphone use, presented a suitable context for implementing and evaluating the MyopiaEd program.
View Article and Find Full Text PDFSelf-reported Myopia in Trinidad and Tobago: A Cross-sectional Study.
Niger Postgrad Med J
October 2024
Department of Clinical Surgical Sciences, Optometry Unit, University of the West Indies, Saint Augustine Campus, Trinidad and Tobago.
Objective: The objective of this study was to determine the prevalence of self-reported myopia in Trinidad and Tobago.
Materials And Methods: This study was a cross-sectional design, and data were collected using a validated structured questionnaire from January to April 2024. Systematic random sampling was used to select participants aged 15 and above to participate.
Vision-related quality of life and near-work visual symptoms in patients with attention-deficit/hyperactivity disorder.
Clin Exp Optom
November 2024
Grupo de Investigación Oftalmología Experimental, Departamento de Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, España.
Clinical Relevance: Attention-deficit/hyperactivity disorder (ADHD) has been associated with visual symptoms that may impact daily activities such as near-work tasks and social interactions. Addressing these visual issues is important for improving the overall quality of life and functional outcomes in individuals with ADHD, particularly in academic and social settings.
Purpose: To investigate the relationship between vision-related quality of life and near-work visual symptoms in patients with ADHD patients.
Assessment of potential myopia risk factors, including chronotype, in Estonian adolescents: a cross-sectional study.
BMC Ophthalmol
November 2024
Eye Clinic, East Tallinn Central Hospital, Ravi 18, Tallinn, 10138, Estonia.
Background: Myopia is a growing healthcare concern worldwide. Increasing evidence suggests that sleep and circadian rhythms may be associated with myopia. Furthermore, the risk factors of myopia have not been studied in the Estonian population to date.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!