AI Article Synopsis
- Noble metal-based nanomaterials, specifically Au eyeball-like nanoparticles with Pd shells, show potential for multifunctional cancer treatment by targeting tumors effectively.
- These nanoparticles are functionalized with folic acid for targeting and Chlorin e6 (Ce6) for photodynamic therapy, which effectively addresses tumor hypoxia and enhances treatment efficacy.
- The synthesized Au@Pd-PEG-FA-Ce6 nanoparticles selectively accumulate in tumor sites, induce cell apoptosis, and demonstrate desirable properties like biosafety and fast delivery, making them promising for breast cancer therapy.
Article Abstract
Noble metal-based nanomaterials offer great potential as cargoes for multifunctional cancer treatment. In this research, Au eyeball-like nanoparticles (NPs) with open-mouthed Pd shells were synthesized and their surface was functionalized with cell-targeting ligand folic acid (FA) and photodynamic agent Chlorin e6 (Ce6). Due to the broad near-infrared (NIR) absorption band of eyeball-like bimetallic Au and Pd, the photothermal therapy effects of this nanomaterial were studied in MCF-7 cancer cells. The anchored Ce6 not only addressed the hypoxia issue of tumor cells but also exhibited remarkable photodynamic efficacy upon irradiation. Results showed that the obtained Au@Pd-PEG-FA-Ce6 (APPFC) NPs were selectively accumulated at the tumor site and induced cell apoptosis effectively due to the target specificity and synergistic phototherapy effect. The high specificity, desirable biosafety, fast delivery, and drug functionalization demonstrated eyeball-like Au@Pd NPs are promising candidate for multifunctional therapy of breast cancer.
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| http://dx.doi.org/10.1021/acsabm.0c00624 | DOI Listing |
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Article Synopsis
- Noble metal-based nanomaterials, specifically Au eyeball-like nanoparticles with Pd shells, show potential for multifunctional cancer treatment by targeting tumors effectively.
- These nanoparticles are functionalized with folic acid for targeting and Chlorin e6 (Ce6) for photodynamic therapy, which effectively addresses tumor hypoxia and enhances treatment efficacy.
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