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Mechanoresponsive Alignment of Molecular Self-Assembled Negatively Charged Nanofibrils. | LitMetric

AI Article Synopsis

  • Researchers developed synthetic molecular fibrils that change from a disordered to an ordered state when subjected to mechanical force, mimicking how actin filaments behave in cells.
  • By using specific amino acids and adjusting pH levels, these fibrils self-assemble into uniform nanofibrils in acidic solutions, which then align in response to external forces.
  • The process of evaporation casting allows for the creation of scalable structures with varied optical properties, showing potential for future applications in advanced optical materials inspired by biological systems.

Article Abstract

Inspired by the mechanoresponsive orientation of actin filaments in cell, we introduce a design paradigm of synthetic molecular self-assembling fibrils that respond to external mechanical force by transforming from a macroscopically disorder state to a highly ordered uniaxial aligned state. The incorporation of aromatic-containing amino acids and negatively charged amino acids lead to self-assembly motifs that transform into uniform nanofibrils in acidic solution. Adjusting the pH level of aqueous solution introduces optimal negative charge to the surface of self-assembling nanofibrils inducing long-range electrostatic repulsion forming a nematic phase. Upon external mechanical force, nanofibrils align in the force direction. Via evaporation casting in capillary confinement, the solvated synthetic self-assembling nanofibrils transform into scalable lamellar domains. Adjusting capillary geometry and drying procedure offers further parameters for tuning the mesoscale alignment of nanofibrils generating a variety of interference colors. The design paradigm of mechanoresponsive alignment of self-assembled nanofibrils as an addition of nanofabrication techniques is potentially employable for realizing biomimetic optical structures.

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Source
http://dx.doi.org/10.1021/acsabm.0c00011DOI Listing

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