The relationship between nitrous oxide sedation and psychosocial factors in the pediatric outpatient setting.

Background: Moderate sedation using nitrous oxide (N O) has become common in pediatric dentistry. However, less is known regarding the role of patients' characteristics and psychosocial factors in their cooperative behavior during dental procedures with N O.

Aims: This study aimed to examine pediatric dental patients' behaviors while undergoing N O sedation and to measure the associations between child's cooperative behavior and demographic, physiological responses, and psychosocial factors.

Methods: In this within-subject observational study, participants received 40% N O/O , by nasal hood, for non-surgical dental procedures. The main outcome measure was the extent of cooperative behaviors, as assessed by the Frankl scale at five timepoints, namely T1: pre-administration of N O, T2: post-administration of N O, T3: dental injection, T4: dental treatment, and T5: post-procedure administration of 100% O . Predictors included age, sex, psychosocial factors reported using the Parenting Style and Dimension Questionnaire and Spence Children Anxiety Scale, as well as pulse rate, respiratory rate, and oxygen saturation. The Wilcoxon signed-rank test and generalized estimation equation were used for data analyses.

Results: In 80 children with a mean age of 7.2 (2.2) years, administration of N O was significantly associated with cooperative behaviors (odds ratio [OR]:2.62, confidence interval [CI]: 1.46-4.70, p = .001) when adjusted for other predictors. There was no interaction between any of the predictors and N O sedation on behaviors. Except for the authoritative parenting style (OR: 1.96, CI: 1.16-3.31, p = .012), which predicted more cooperative behaviors, other predictors were not associated with behavioral outcomes.

Conclusion: In children sedated with N O, behavior was independent of the child's demographic and psychosocial factors. While sedated, demographics, vital signs, and anxiety did not contribute to behavior management. However, screening for parenting style may help predict the child's behavioral response.