Introduction: Rifaximin use in combination with lactulose is associated with a decreased risk of overt hepatic encephalopathy (HE).

Methods: We prospectively evaluated the impact of an interruptive electronic medical record alert to indicate rifaximin for patients with cirrhosis and HE on lactulose.

Results: The intervention was associated increased rifaximin utilization, particularly for nongastroenterology and hospitalist services odds ratio 1.20 95% confidence interval (1.09-1.31). For patients with HE, the intervention was associated with a lower readmission risk-adjusted subdistribution hazard ratio 0.63 95% confidence interval (0.48-0.82).

Discussion: An interruptive alert in the electronic ordering system was associated with a lower risk of readmissions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034761PMC
http://dx.doi.org/10.14309/ajg.0000000000001608DOI Listing

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