Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Collected in the South China Sea.

J Nat Prod

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.

Published: January 2022

Five new dolabellane diterpenes, clavularinlides A-E (-), and four new racemic elemane alkaloids, clavulacylides A-D (-), together with one known compound (), were isolated from the soft coral collected in the South China Sea. Their structures were elucidated by 1D and 2D NMR, HRESIMS, calculated ECD, and DP4+ probability analyses. Compounds - showed anti-inflammatory activity in the zebrafish assay.

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http://dx.doi.org/10.1021/acs.jnatprod.1c01103DOI Listing

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