AI Article Synopsis
- The study aimed to investigate the relationship between oxidative stress and glucose-6-phosphate dehydrogenase (G6PD) activity in patients with type II diabetes mellitus (DM).
- It involved 48 participants, comparing G6PD activity, protein carbonyl, and total thiol levels between diabetic patients and healthy individuals.
- Findings revealed that lower G6PD activity was linked to higher oxidative stress markers and poorer blood sugar control, suggesting G6PD could serve as a biomarker for oxidative stress in diabetes.
Article Abstract
Background: The present study aimed to assess the correlation of oxidative stress glucose-6-phosphate dehydrogenase (G6PD) activity in type II diabetes mellitus (DM) patients.
Methodology: Forty-eight type II DM patients and healthy subjects were recruited. In all, G6PD activity, protein carbonyl, and total thiol levels were measured.
Results: The mean glycated hemoglobin (HbA1c) was 9.4% in Group I and 5.2% in Group II, G6PD activity was 6.5 U/gHb in Group I and 8.2 U/gHb in Group II, protein carbonyl was 14.2 nmol/mg protein in Group I and 3.5 nmol/mg protein in Group II, and total thiol level was 204.7 μmol/mL in Group I and 318.2 μmol/mL in Group II. In Group I, G6PD activity positively correlated with total thiol ( = 0.62) and negatively correlated with protein carbonyl ( = -0.73) and HbA1C ( = -0.67), protein carbonyl positively correlated with HbA1C ( =0.45) and negatively correlated with total thiol ( = -0.84), and total thiol negatively correlated with HbA1c ( = -0.30).
Conclusion: G6PD may be considered a biomarker of oxidative stress and poor glycemic control in diabetic patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686861 | PMC |
| http://dx.doi.org/10.4103/jpbs.jpbs_291_21 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!