AI Article Synopsis
- * Plasmonic nanoparticles are being developed to improve RNAi therapeutics through efficient delivery, photothermal properties, and better detection for cancer.
- * The review outlines recent advancements in using plasmonic nanoparticles for miRNA delivery, while discussing challenges and future prospects in RNAi-based cancer diagnosis and treatment.
Article Abstract
RNA interference (RNAi) is being extensively investigated as a potential therapeutic strategy for cancer treatment. However, RNAi-based therapeutics have not yet been used to treat cancer because of their instability and the difficulty of microRNA (miRNA) delivery. Plasmonic nanoparticle-based RNAi nanotherapeutics have been developed for accurate and sensitive diagnosis and a strong therapeutic effect on cancers by leveraging their ease-of-use and specific properties such as photothermal conversion. In this review, recent strategies and advances in plasmonic nanoparticle-based miRNA delivery are briefly presented to facilitate the detection and treatment of several cancers. The challenges and potential opportunities afforded by the RNAi-based theragnosis field are discussed. We expect that the RNAi-integrated plasmonic nanotherapeutics discussed in this review can provide insights for the early diagnosis and effective treatment of cancer.
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| http://dx.doi.org/10.1016/j.jconrel.2022.01.012 | DOI Listing |
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