AI Article Synopsis
- Chimeric antigen receptors (CARs) can be engineered to redirect T cells to target specific surface antigens in cancer therapy.
- Researchers, led by Heitzeneder et al., focused on enhancing CAR designs to effectively target low-density antigens, specifically cerebroglycan (GPC2).
- Their optimized CAR design demonstrated strong effectiveness in pre-clinical studies using neuroblastoma models.
Article Abstract
Chimeric antigen receptors (CARs) allow redirection of T cells against any surface antigen. However, CARs require optimization to achieve activity against low-density antigens. Heitzeneder et al. perform an iterative adjustment of CAR components to reach a design for targeting cerebroglycan (GPC2) that shows potent pre-clinical activity in neuroblastoma models.
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| http://dx.doi.org/10.1016/j.ccell.2021.12.010 | DOI Listing |
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