Two new triterpenes isolated from C. Y. Cheng et W. L. Sha and their antiproliferative activities.

Two new triterpenes, 3, 7-dihydroxyolean-12-en-11-one (1) and 3--acetyl-7-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3-hydroxyolean-12-en-11-one (3), -amyrin (4), lup-20(29)-ene-1, 3-diol (5) and 1, 3-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of C. Y. Cheng et W. L. Sha. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and IR experiments. Compounds (3-6) were isolated from for the first time. Compounds - were evaluated for their antiproliferative activities against Eca-109, PANC-1, EJ and HeLa cell lines. The results showed that compounds - displayed a certain degree of inhibitory effects against the proliferation of various human cancer cell lines.