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Background: Many α -agonists are commonly used for sedation and analgesia in ruminants.
Introduction: The present study aims to compare the sedative and physiological effects of intravenous (IV) administration of xylazine, detomidine, medetomidine and dexmedetomidine in goats.
Methods: Ten healthy goats aged 6 ± 1 months and weighing 15 ± 2 kg were used in experimental, crossover Latin square, randomised and blinded study. Animals were assigned to five IV treatments: control (normal saline); xylazine (100 μg kg ); detomidine (50 μg kg ); medetomidine (20 μg kg ) and dexmedetomidine (5 μg kg ). The degree of sedation was investigated using a numerical ranking scale of 0-10. Sedation scores were compared at each time using nonparametric (Kruskal-Wallis and Mann-Whitney U) tests.
Results: Heart rate (HR), respiratory rate (RR), rectal temperature (RT), ruminal motility and capillary refill time (CRT) were performed before (baseline) and after drug administration. Animals in α -adrenergic agonist treatments were sedated at 5-60 min. There were no significant differences among α -adrenergic agonist treatments at 5-60 min in sedation scores. HR significantly decreased from baseline 5-90 min after α -adrenergic agonists' administration. Ruminal motility was decreased in α -adrenergic agonist treatments at 5, 90 and 120 min and absent at 10-60 min. A significant decrease from baseline in RR was detected between 30 and 90 min after α -adrenergic agonists' administration. RT was unchanged in any treatment for 120 min. CRT was less than 2 s at all time points following each treatment.
Conclusions: The duration of sedation was up to 60 min after IV administration of xylazine (100 μg kg ), detomidine (50 μg kg ), medetomidine (20 μg kg ) and dexmedetomidine (5 μg kg ) in goats in this study. No significant differences were detected between xylazine, detomidine, medetomidine and dexmedetomidine in goats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122450 | PMC |
| http://dx.doi.org/10.1002/vms3.732 | DOI Listing |
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