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The incredible story of ophiobolin A and sphaeropsidin A: two fungal terpenes from wilt-inducing phytotoxins to promising anticancer compounds.
Nat Prod Rep
March 2024
Institute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125 Bari, Italy.
Covering: 2000 to 2023This review presents the exceptional story of ophiobolin A (OphA) and sphaeropsidin A (SphA), a sesterterpene and a diterpene, respectively, which were initially isolated as fungal phytotoxins and subsequently shown to possess other interesting biological activities, including promising anticancer activities. Ophiobolin A is a phytotoxin produced by different fungal pathogens, all belonging to the genus. Initially, it was only known as a very dangerous phytotoxin produced by fungi attacking essential cereals, such as rice and barley.
View Article and Find Full Text PDFGlioblastoma: The Weed of the Brain.
J Vis Commun Med
April 2022
Liverpool School of Art and Design, Liverpool John Moores University, Liverpool, England.
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