AI Article Synopsis

  • Cardiovascular diseases, particularly coronary artery disease, are the leading global cause of death, mainly due to atherosclerotic plaques but less commonly due to non-atherosclerotic lesions.
  • The article highlights a gap in knowledge about the causes, prevalence, and treatments for these less common coronary lesions, including spontaneous coronary artery dissection and others.
  • Optical coherence tomography (OCT) is introduced as an advanced imaging technique that helps overcome the diagnostic limitations of traditional methods, providing detailed, histological-like information about these coronary lesions in real-time.

Article Abstract

Cardiovascular diseases are the main cause of death worldwide, with coronary artery disease being the predominant underlying etiology. The most prevalent coronary lesions are represented by the atherosclerotic plaques, in more than 85% of cases, but there are several other non-atherosclerotic lesions such as spontaneous coronary artery dissection and/or hematoma and spontaneous recanalization of coronary thrombus, which are less common, approximately 5% of cases, but with similar clinical manifestations as well as complications. There are insufficient data regarding the pathological mechanism, true prevalence and optimal treatment of these kind of coronary lesions. Optical coherence tomography (OCT) is an intracoronary imaging technique, developed in order to overcome the diagnostic limitations of a standard coronary angiography and has an extremely high resolution, similar to that of a usual histological evaluation of a biopsy sample, thus, OCT provides a histological-like information, but in a in vivo environment. The aim of this article is to review the current knowledge regarding non-atherosclerotic coronary lesions, with an emphasis on the importance of OCT for optimal identification, characterization of pathogenic mechanisms and optimal treatment selection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745669PMC
http://dx.doi.org/10.3390/jcm11010265DOI Listing

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