Nine new sesquiterpenoids (-) were isolated from ethyl ether extract of agarwood originated from sp., including three novel sesquiterpenoids (-) derived from zizaane, together with six zizaane-type sesquiterpenoids (-). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC value of 62.22 ± 1.27 μM.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746309 | PMC |
| http://dx.doi.org/10.3390/molecules27010198 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Plant.
Molecules
December 2021
Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Nine new sesquiterpenoids (-) were isolated from ethyl ether extract of agarwood originated from sp., including three novel sesquiterpenoids (-) derived from zizaane, together with six zizaane-type sesquiterpenoids (-). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data.
View Article and Find Full Text PDFAntartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a sp. Isolated from an Antarctic Marine Sediment.
Mar Drugs
April 2018
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea.
Antartin (), a new zizaane-type sesquiterpene, was isolated from sp. SCO736. The chemical structure of was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data.
View Article and Find Full Text PDFStrepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete Streptomyces sp. SCSIO 10355.
J Nat Prod
December 2013
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S)-4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!