AI Article Synopsis
- Macrophages play key roles in inflammation, recovery, and repair processes by exhibiting diverse functions.
- Their reactions during inflammation are influenced by their ability to modify bioactive lipids, such as fatty acids and oxylipins.
- This review focuses on the fatty acids and oxylipins produced by macrophages, discussing their impact on type 1 and type 2 immune responses and highlighting important lipidomic research that enhances our understanding of macrophage polarization.
Article Abstract
Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in part, to their ability to rearrange their repertoire of bioactive lipids, including fatty acids and oxylipins. This review will describe the fatty acids and oxylipins generated by macrophages and their role in type 1 and type 2 immune responses. We will highlight lipidomic studies that have shaped the current understanding of the role of lipids in macrophage polarization.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746402 | PMC |
| http://dx.doi.org/10.3390/molecules27010152 | DOI Listing |
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