AI Article Synopsis
- The study demonstrates the creation of affordable Surface Enhanced Raman Spectroscopy (SERS) sensors using Lee-Meisel Ag colloids on filter paper through natural sedimentation or centrifugation.
- The sensors were thoroughly characterized using techniques like optical microscopy, SEM, and UV-Vis spectroscopy, highlighting their effective morphological and plasmonic properties.
- These cost-effective sensors can accurately quantify the anti-epileptic drug Perampanel at low concentrations by spinning them during measurements to reduce heating effects and enhance uniformity.
Article Abstract
The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained by depositing Lee-Meisel Ag colloids on filter paper either by natural sedimentation or centrifugation. We have characterized the morphological and plasmonic features of the sensors by optical microscopy, SEM, and UV-Vis spectroscopy. Such sensors can be used to quantify by SERS the anti-epileptic drug Perampanel (in the concentration range 1 × 10-5 × 10 M) by spinning them during the micro-Raman measurements on the top of a custom device obtained from spare part hard disk drives. This approach minimizes laser-induced heating effects and allows averaging over the spatial non-uniformity of the sensor.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746616 | PMC |
| http://dx.doi.org/10.3390/molecules27010030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!