Today's stamping simulations are realized by ignoring the elastic deformation of the press and tooling system through the assumption of a rigid behavior and a perfect press stroke. However, in reality, the press and tool components deform elastically and are one of the major error sources for the final adjustment and blue-spotting of the dies. In order to tackle this issue, a new approach is proposed in this study that substitutes the press stiffness by means of a substitutive model composed of cost-effective shell and beam elements. The substitute model was calibrated using full-scale measurements, in which a 20,000 kN trial press was experimentally characterized by measuring its deformation under static loads. To examine the robustness of the substitute model, a medium-size tool and a large-size tool were simulated together with the substitutive model. To this end, a B-pillar tool was re-machined based on the substitute-model results and a new cambering procedure was proposed and validated throughout the blue-painting procedure. The newly developed substitute model was able to replicate the global stiffness of the press with a high accuracy and affordable calculation time. The implementation of the findings can aid toolmakers in eliminating most of the reworking and home-line trials.
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http://dx.doi.org/10.3390/ma15010279 | DOI Listing |
Background: Women involved in the criminal legal system have elevated rates of opioid use disorder, which is treatable, and HIV, which is preventable with pre-exposure prophylaxis (PrEP). There are significant social and structural barriers to integrated delivery of PrEP and medications for opioid use disorder (MOUD), limiting women's ability to access these life-saving interventions. In a two parallel-arm randomized controlled trial, we are assessing an innovative eHealth delivery model that integrates PrEP with MOUD and is tailored to meet the specific needs of women involved in the criminal legal system.
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January 2025
National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University; CSU-Sinocare Research Center for Nutrition and Metabolic Health, Xiangya School of Public Health, Central South University, Furong Laboratory, Changsha, 410011, China.
Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes (T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility, and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment.
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January 2025
Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Via Taramelli 3B, 27100, Pavia, Italy.
Perfluorinated compounds (PFAS) are well recognized toxic pollutants for humans, but if their effect is equally harmful for healthy and fragile people is unknown. Addressing this question represents a need for ensuring global health and wellbeing to all individuals in a world facing the progressive increase of aging and aging related diseases. This study aimed to evaluate the impact of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) exposure on development and skeletal phenotype using the osteogenesis imperfecta (OI) zebrafish model Chihuahua (Chi/+), carrying a dominant glycine substitution in the α1 chain of collagen I and their wild-type (WT) littermates.
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D3 Drug Tech Lab Pvt Ltd, Chennai, Tamilnadu, India.
Lung cancer is the leading cause of mortality in both men and women due to genetic and epigenetic modifications. Our study focuses on fabricating phenmiazine ring leads by a functional group-based drug design to inhibit p53 -7A1W and MDM2-7AU9 proteins responsible for cancer cell growth. One hundred molecules are designed and allowed to bind inside the active site of 7A1W and 7AU9 protein using a glide dock platform and subjected to find MMGBSA.
View Article and Find Full Text PDFWaste Manag
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Idaho National Laboratory, Idaho Falls, ID, USA.
Flexible plastic packaging (FPP) is a growing waste source in the United States. Currently, FPP has a recycling rate of only 2% in the U.S.
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